Mycoplasma bovis mainly affects cattle and has little effect on other production animals.

[1] Wyoming Game and Fish is reporting that the North American pronghorn is now affected by the disease with very high mortality.

Generally speaking, the higher the somatic cell count, the lower the milk quality.

Some calves have swollen joints that are so painful that they will be reluctant to walk to the feed and water bunks.

In rare cases calves can have spinal issues, tiredness, irritability, muscle atrophy, licking, chewing and biting.

Mycoplasma bovis can be analyzed with culture, PCR (polymerase chain reaction) or serology.

A collaboration between six different European laboratories (CoVetLab) showed that the different in-house PCR that were used worked well A European interlaboratory trial to evaluate the performance of different PCR methods for Mycoplasma bovis diagnosis The CoVetLab project also evaluated three different serological methods and found that two of them were performing well A European inter-laboratory trial to evaluate the performance of three serological methods for diagnosis of Mycoplasma bovis infection in cattle using latent class analysis Mycoplasma bovis was first isolated in the United States from the milk of a mastitic cow in 1961.

[9] It was initially described as Mycoplasma agalactia var bovis by Hale and colleagues, on the basis of biochemical reactions and its association with bovine mastitis.

The estimated loss in Europe due to Mycoplasma bovis is approximately €576 million per year.

Draxxin (Tulathromycin) and Resflor Gold are the only drugs approved for treating Mycoplasma bovis in cattle but Florfenicol (Nuflor) and Batril can also be used.