[1][2] Nyein was born on 25 January 1909 in Mandalay, British Burma, son of U Nyi, a goldsmith, and mother Daw Chit Oo, a lacquerware merchant.

[5] One of his earlier songs written in 1939 was "Eindawya Paya Zay" in support of Mandalay's central Zegyo Market shopkeepers' all out strike against Section 23(7) enacted by the British colonial government when they relocated to the Eindawya Pagoda precincts.

[7] After the war in 1945, when Mandalay held a major sporting event, Myoma Nyein wrote for the occasion songs titled "Olympics" and "Yin Dago Me" (Beauty Contest).

[3] His song for the 1947 Burmese New Year Thingyan "Shwe Man Taung Yeikkho" aka "Mya Nandar" (In the Shade of Mandalay Hill) has become a perennial classic during the festive season.

[3] His oldest daughter Tin Kyi was married to the artist Paw Oo Thet.