In animal models and limited human studies, myostatin inhibitors have increased muscle size.
[7] Creatine, a popular workout supplement, has shown some myostatin inhibitory effects in preclinical studies.
[12] Clinical trials for muscular dystrophy have not proven successful in generating functional improvements compared to placebo.
[13] Research is ongoing on the potential use of myostatin inhibitors for motor neuron diseases like spinal muscle atrophy and amyotrophic lateral sclerosis.
[14] Due to myostatin's effect as a negative regulator of bone, its inhibition has also been considered for orthopedic diseases such as rheumatoid arthritis.