It is located 3 miles (5 km) southwest of the central business district of Myrtle Beach, in Horry County, South Carolina, United States.

The Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2017–2021 categorized it as a small-hub primary commercial service facility.

[14] Until 1993, both MYR and Myrtle Beach AFB jointly used the main runway; this limited civil operations to 30 landings per day and led to a local business movement to build an entirely new airport.

[23] Direct Air connected a number of airports to Myrtle Beach from 2007 until 2012, when it abruptly filed for Chapter 7 bankruptcy and ceased operations.

Negotiations are currently underway between LIFT, MYR, the City of Myrtle Beach about a suitable long-term facility for the flight training program.

In July 2010, the FAA approved a $4.50 passenger facilities charge on all airline tickets to and from MYR in order to defray part of the cost for the terminal upgrade.

These documents show the early stages of a legally required 20-year master plan, that began in 2018 but was put on pause due to the pandemic.

[31] On April 8, 2022, it was announced that the airport planned a $35 million expansion that will be primarily funded by the federal Infrastructure Investment and Jobs Act that was signed into law by President Joe Biden.

The proposed renovations would include adding 4-5 new gates onto the end of the "A" gate that is located on the south side of the building, more fuel storage that will add 100,000 gallons in fuel storage capacity in case of future supply crunches, security checkpoint that will alleviate the pressure created by the current TSA bottleneck, and add more space for restaurants and retail.

The proposed expansion would bring the total number of gates to 18 at the airport and is part of an effort to keep up with growth, as well as the travelers, including the newly completed parking canopy over the rental car lot.

In the year ending April 30, 2023, the airport had 149,968 aircraft operations, average 411 per day: 55% air taxi, 22% airline, 18% general aviation, and 5% military.