Myrtle Creek is a short tributary of the South Umpqua River in Douglas County in the U.S. state of Oregon.

Its main stem, formed by the confluence of two forks just south of the city of Myrtle Creek, is only about 1 mile (1.6 km) long.

The unbroken forest and its stream network provide habitat for species such as coho salmon and the northern spotted owl as well as clean drinking water for humans.

Recreation in the watershed includes hiking, mushroom gathering, camping, horseback riding, and a wide variety of other outdoor activities.

In 1891, China Ditch, a 33-mile (53 km) artificial waterway dug with the help of hundreds of Chinese workers, began diverting water from Little River in the North Umpqua River basin to North Myrtle Creek to make hydraulic dredging with large machines possible near the headwaters during all seasons .