The road starts 36 km east of Córdoba at Montoro (Junction 356 of the Autovía A-4).

Thereafter the road follows the Autovía A-43 before branching north to cross the A-4 again at Puerto Lapice, south of the Montes de Toledo.

21 km to the east the road passes Alcázar de San Juan and the Autovía CM-42 which is an upgrade of the CM-400.

The road reaches Mota del Cuervo with a junction on the N-301 and Autopista AP-36, before passing the Castle of Belmonte 15 km later.

After a junction with the Autovía A-3 (155 km) in La Almarcha the road passes along the valley of the Rio Jucar to Cuenca, where it crosses N-320.