Methylephedrine, sold under the brand name Metheph among others, is a sympathomimetic medication described as an antiasthmatic agent and used to treat coughing and nasal congestion.

[3][4][1] It is reported to be used in various over-the-counter cough and cold preparations throughout the world, including Japan.

[7][8][9] Methylephedrine shows reinforcing effects, a measure of addiction and misuse potential, in monkeys.

[5] The occupancy of the dopamine transporter (DAT) by racemic methylephedrine has been studied.

[3][4][16] Brand names of methylephedrine include Metheph, Methy-F, and Tybraine, among others.

[10] It is one of the four constituents of BRON, a Japanese over-the-counter cough medicine with reports of misuse.