Major towns and cities along the route of the N2 include Tema, Kpong, Atimpoku, Ho, Hohoe, Nkwanta, Bimbila, Gushiegu, Nakpanduri, Yendi, Bawku.

There has been major upgrade works completed in 2020 converting the roundabout at the end of the Accra-Tema motorway to improve the traffic flow at this very busy junction of the N1 and N2.

[3] It then proceeds north through the town of Afienya and runs by the western side of the Shai Hills Resource Reserve before entering the Eastern region.

In the Eastern region, the route runs north through Kpong where it shares a junction with the N3 and then on to Atimpoku and Senchi before it traverses the Volta Lake via the Adomi Bridge.

In the Upper East Region, the N2 runs north through Garu and Bawku, where it intersects with the N11 before continuing on to Kulungugu on the border with Burkina Faso.