At the border, it connects to the Belgian N4, which leads to Arlon, Namur, Wavre, and Brussels.

At its eastern end, the N6 meets the N51 (boulevard de la Foire), on the edge of the Ville Haute quarter of Luxembourg City.

The road proceeds to pass the Lycée Technique Josy Barthel in Mamer, before reaching another junction with the A6.

Continuing westwards, the N6 runs through the towns of Capellen and Windhof, before reaching Steinfort, on the border with Belgium, whereupon it meets the Belgian N4.

The N6 is a part of the Liberty Road, the commemorative way marking the route of the Allied forces from D-Day in June 1944.