[5] In January 2016, NEO secured its first listing: the Invesco PowerShares DWA Global Momentum Index ETF, which began trading on March 31, 2016.

[10][11][12] On April 20, 2017, Mackenzie Financial announced the imminent launch of a new Global High Yield Fixed Income ETF, becoming the fifth issuer to list on the NEO Exchange.

[19] Nobilis Health was previously listed on the TSX and chose to return to Canada because of NEO's focus on "liquidity, their investor communication services and the streamlined disclosure-based listing model, coupled with their unwavering dedication to meeting the needs of public companies and investors".

[25][26][27] Cboe Canada has consistently advocated for enhanced access to consolidated market data for Canadian investors, claiming retail investors and the majority of investment advisors have access only to a partial view of market as less than 35% of ETF trading activity and less than 60% of overall trading activity in TSX and TSXV-listed securities is reflected in TSX and TSXV data.

[30] In response to the Competition Bureau's decision to close their investigation, the NEO Exchange called on the Canadian Securities Administrators to “mandate access to consolidated market data for all investors, including retail investors and their investment advisors.”[31] NEO Connect is a fund distribution platform offered by Cboe Canada, allowing investment products not listed on an exchange be purchased and redeemed by investors, working through an IIROC dealer, in a similar fashion to publicly traded securities and exchange traded funds.