A NOG (NOD/Shi-scid/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA) in 2000.
Thus, the mouse can be the best model as a highly efficient recipient of human cells to engraft, proliferate and differentiate.
[1] This unique feature offers a great opportunity for enhancing therapy researches of cancer, leukemia, visceral diseases, AIDS, and other human diseases.
It also provides applications for cancer, infection, regeneration, and hematology researches.
NOG mouse has multiple immunodeficiencies that are principally derived from three strains of mice: 1) NOD/Shi inbred strain, 2) SCID, 3) IL-2Rγnull.