The route was assigned in the early 1930s and eliminated in 1980 as part of a highway maintenance swap between the state of New York and Rensselaer County.

The route headed to the northeast, running alongside Wynants Kill as it followed Campbell Avenue through the residential southern portion of Troy.

The route and the river crossed paths after 0.75 miles (1.21 km), with Wynants Kill proceeding southeastward toward the hamlet of Wynantskill and NY 154 continuing northeastward to a junction with Spring Avenue, a street linking NY 154 to the downtown district.

This section of the route passed through a mostly rural portion of Rensselaer County as it gradually headed southeastward toward an intersection with NY 355.

[3][4] It was extended southwestward along Spring and Campbell Avenues to a new terminus at US 4 in the late 1970s,[6][8] but was eliminated on May 14, 1980,[5] as a result of a highway maintenance swap between the state of New York and Rensselaer County that took effect on April 1 of that year.