At this junction, maintenance jurisdiction switches from the New York State Department of Transportation to Albany County, and the route becomes concurrent with CR 157.

Soon leaving the city of Albany, the routes cross into the town of Colonie after a short stint back in Guilderland.

Turning further to the northeast through Colonie, NY 155 and CR 157 pass through the hamlet of Karner and cross over tracks used by Amtrak.

The routes reach a junction with NY 5 (Central Avenue) and the surrounding commercial area.

[4] Still in the town of Colonie, NY 155 and CR 157 continue east along Watervliet–Shaker Road, passing the Memory's Garden Cemetery.

Passing north of Stump Pond, the routes soon turn northeast through the hamlet of Shakers, where widens into a four lane divided highway.

[4] NY 155 and CR 153 continue northeast along Wolf Road, parallel to Interstate 87 (the Adirondack Northway).

Continuing east through the town of Colonie, the route soon reaches a junction with US 9 (Loudon Road) just south of the Latham Circle.

Passing a small pond, the route remains residential, soon crossing over railroad tracks into the city of Watervliet.