Its northern terminus is located at a junction with NY 3 in the hamlet of Morrisonville, near Clinton County Airport.

It briefly runs west until it reaches the grounds of the Peru Central School District building, and makes a sharp curve to the north at the intersection of Clinton County Route 37 (CR 37; River Road), replacing the trajectory of CR 39 (Jarvis Road).

Along the way it turns north again as it passes a local Veterans of Foreign Wars post, then after the intersects a local road named Blake Road curves back to the northwest before the intersection with Mason Avenue just before entering the former village of Schuyler Falls.

From that point it intersects the northern terminus of CR 40 then crosses a bridge over the Salmon River while curving from northwest to north-northwest before a brief overlap with CR 33 between Norrisville Road (which leads to Macomb State Park) and Salmon River Road.

North of the community, the route runs through more local farmland and at one point intersects the western terminus of CR 32, a road known as Irish Settlement Road, which leads to NY 22 at exit 36 on the Adirondack Northway and the western edge of the Plattsburgh International Airport.