Crossing north through the hamlet of Middle Granville, NY 22A parallels the Mettawee River, reaching a junction with the eastern terminus of County Route 23 (CR 23).

[3] After a short eastern segment, NY 22A bends northeast again, entering the hamlet of Raceville, a small residential community.

Rapidly approaching the Vermont state line, the route continues northeast through Granville, soon crossing into the town of Hampton.

In Hampton, NY 22A turns northwest at a fork that marks the beginning of CR 20, which runs to the state border.

Continuing a parallel with the Vermont state line, the route soon bends north and reaches the Poultney River, which marks the northern terminus of NY 22A.