Lewington has played the roles of Maggi in drama the Dream Team and Abi Steel in the soap opera Family Affairs.
In October 2006, it was announced that Lewington had joined the cast of the BBC One medical drama Holby City as Senior House Officer Maddy Young.
She also appeared in the charity telethon Children in Need, in which she alongside her Holby City co-stars was performing a version of "Hung Up" by Madonna.
[6] In 2008, Lewington appeared in a Holby City vs. Casualty special episode of BBC Two quiz show The Weakest Link.
In January 2018, it was reported that Lewington had a recurring role as Greta Sienna in the final season of supernatural drama series The Originals.