[1] It branches off Minami-Osaka Line at Furuichi in southern suburbs of Osaka.

The line connects cities of Habikino, Tondabayashi and Kawachi-Nagano in Osaka Prefecture, terminates at Kawachinagano with connection to Nankai Electric Railway Kōya Line.

The Nagano Line was constructed and opened between 1898 and 1902 as the sole line of Kayō Railway (河陽鉄道, Kayō Tetsudō) who aimed to connect inland town Kawachinagano to Kashiwara on the Kansai Main Line (then of Kansei Railway (関西鉄道, Kansei Tetsudō, also read as Kwansei, Kansai)).

The line was electrified at 1500 VDC in 1923, and the company merged with Kintetsu in 1944.

The Furuichi - Kishi section was duplicated in 1957, and extended to Tondabayashi in 1974.