Karri received widespread recognition in 2018 for writing social Cold War drama Stanley Cage that is being turned into a feature film to be released in 2020.

Karri's "Where are you Sophia" which premiered in Tribeca film festival during 2010 garnered huge commercial and critical success paving the way for many social dramas that were written by him and was produced by Eternal mind media group.

Filmmaking[4] was Karri's first love, but he had to pursue his career in finance[5] and Information technology and only got into the film business after years of being an understudy to successful producers and directors in his field.

In 2009, Nagendra Karri directed and produced Where are you Sophia?, a psychological suspense thriller which had a worldwide release in early Feb 2010 and premiered in the Cannes film festival, IFFI and Tribeca.

Skanda media under Karri's leadership has partnered with Chinese investment fund to undertake a major studio construction project that is expected to be completed in 2022.