Nagykálló (Hungarian: Nagykállói járás) is a district in southern part of Szabolcs-Szatmár-Bereg County.

Nagykálló is also the name of the town where the district seat is found.

The district is located in the Northern Great Plain Statistical Region.

Besides the Hungarian majority, the main minorities are the Roma (approx.

2,500 persons in Nagykálló District did not declare their ethnic group at the 2011 census.