Natsume was born on January 23, 1980, in Sakai, Osaka, Japan (Her birthdate has usually been reported as 1982 and it is still listed as such on her SOD profile,[2] but her official website has her birth year as 1980).
[4] Natsume appeared for the Soft On Demand adult video company as the host of their AV Awards ceremony at Tokyo's Shinjuku Century Hyatt hotel on November 26, 2003.
[7][8] In November 2005, she appeared in her first bukakke movie, Nana Natsume Showered by Semen directed by Kazuhiko Matsumoto, the man who is usually credited with inventing that genre of Japanese pornography.
[9] In December 2005 she did her video Stripper, a lesbian love story with former SOD star Kurumi Morishita, directed by ex-SOD director TOHJIRO.
[13] She also earned mention in a Mainichi Shimbun story in 2006 by starring in Dirty DVD for Girls, a pornographic video targeted for women.
Her retirement video, released in October 2007, was an 8 disk, over 16 hour package with scenes chronicling her entire body of work from her debut.
[3][19] She also had a small role in the TV Asahi comedy-drama The Aaah Detective Agency (Aatantei jimusho - ああ探偵事務所) which ran for 11 weeks from July to September 2004.
[21] She also had a featured role playing Rumi Osaki in the TV Tokyo cosplay ghost story Guren Onna (ぐれんオンナ) broadcast in 12 episodes from January 11 to March 28, 2008.
This Hong Kong-Japanese production is a remake of the classic 1972 Japanese exploitation film Female Convict 701: Scorpion and according to one review "Nana Natsume ... steals every scene she’s in".
[32] Natsume was the voice of a character in the Sega video game Ryu Ga Gotoku 2 (龍が如く2) or Yakuza 2 for PlayStation 2 released on December 7, 2006.
In her article, in which she gave advice to men seeking success in the area of romance, she stressed the virtues of good grooming and personal hygiene to her reading audience.