After her clerkship, Judge Brasel worked in private practice as an associate with the Minneapolis law firm of Leonard, Street and Deinard (now Stinson).

[4][5] Judge Brasel is the former Chair of the Board of Directors of the Domestic Abuse Project in Minneapolis.

[6] On February 12, 2018, President Donald Trump announced his intent to nominate Brasel to an undetermined seat on the United States District Court for the District of Minnesota as part of a bipartisan package of judicial nominees which included Minneapolis lawyer Eric Tostrud.

President Trump nominated Brasel to the seat vacated by Judge Ann D. Montgomery, who assumed senior status on May 31, 2016.

[12] In October 2020, Brasel upheld a state court ruling, holding that ballots received seven days after the 2020 election must be counted.