[4][5] He received his Bachelor of Arts from the University of Notre Dame, magna cum laude, in 2000 and his Juris Doctor from Harvard Law School in 2003.

[4][5] Locher served as a law clerk for Judge John R. Gibson of the United States Court of Appeals for the Eighth Circuit from 2003 to 2004.

[4] He was then a partner at Belin McCormick, P.C., in Des Moines, Iowa from 2013 to 2021, specializing in commercial litigation, white-collar criminal defense, and appeals.

[9] On February 7, 2022, Senators Charles Grassley and Joni Ernst recommended Locher to fill a vacancy on the Southern District of Iowa.

President Biden nominated Locher to the seat vacated by Judge John Alfred Jarvey, who retired on March 18, 2022.