Nano Assault Neo is a twin-stick multidirectional shooter developed and published by Shin'en Multimedia and released on the Nintendo eShop for the Wii U.

[3] The object of the game is to eradicate the microscopic deadly Nanostray[a] virus, before it wipes out humanity.

[4] Players pilot a small capsule over various body cells and are required to fire upon enemy virus particles.

Players can also collect tokens which can be used to purchase power-ups in-between levels, such as shields and special items.

"[7] IGN gave it a 9/10, strongly praising its graphics, calling it "a visual spectacle.