Englishman George Hoffman established a trading post at the location of present-day Napaimute in 1906.

The middle Kuskokwim Valley was seeing and influx of gold prospectors at that time and Hoffman's became an important supply and trade center.

Current efforts to revitalize the community are evident by the set up of a sawmill in 2001, tribal operations in 2002, and an airport feasibility study launched in 2004.

Georgetown is located at 61°32′N 158°40′W / 61.533°N 158.667°W / 61.533; -158.667 on the north bank of the upper Kuskokwim River 28 miles east of Aniak in the Kilbuck-Kuskokwim mountains.

It was classified as an unincorporated Alaskan Native Village Statistical Area (ANVSA) in each successive census.