Upper Kalskag (Russian: Аппер-Калскаг) is a city in Bethel Census Area, Alaska, United States.

Upper Kalskag is a traditional Yup'ik village, with a culture centered on subsistence activities.

The founding residents were from the native village of Kaltkhagamute, four miles down river.

The Russian explorer Lavrenty Zagoskin reported a population of 120 in 1843 for Kaltkhagamute (Khalkagmute).

George Morgan, a German immigrant who founded Georgetown, established a general store and post office in 1932.

Paul N. Kameroff Sr. also established a general store, a pool hall, and a coffee shop around 1930.

Upper Kalskag is accessible only by small plane, boat, and automobile via the river "ice road" (Winter only).