330s BCE), was an ancient Egyptian high official, known for having witnessed the conquest of Persian Egypt by the hands of Alexander the Great.

Details about Sematawytefnakht's life are known by his limestone funerary stela – commonly referred as the Naples Stela – which was originally placed in a temple at Herakleopolis Magna, then brought to the temple of Isis at Pompeii and now exhibited at Naples National Archaeological Museum (inv.

[1] Sematawytefnakht entered in Persian military service under Darius III and was called to fight in the Battle of Issus (333 BCE) against Alexander's army.

[2][4] In his stela, he claimed that Heryshaf, the local deity of his hometown, appeared to him in a dream and warned him of the danger he would risk by fighting the battle.

[2] Sematawytefnakht should not be confused with the namesake officer who, some three centuries earlier during the 26th Dynasty, escorted Psamtik I's daughter Nitocris I to Thebes for her adoption as Divine Adoratrice of Amun.