[1] He is best known for his role as forensic expert Dr. R. P. Salunkhe in the detective television series C.I.D..[2][3][4][5] Gupta was born in Jaipur, Rajasthan, and was the youngest child of a business family.

As a young student, he loved to study science and mathematics, though when he arrived in college, he started to read about arts and cinema.

[6] Gupta started his acting career with DD National's Wagle Ki Duniya in 1988.

[2][8][9] In 2014, Narendra Gupta appeared in Kaun Banega Crorepati with Shivaji Satam, Aditya Srivastava and Dayanand Shetty.

[10] Gupta has acted in many popular television serials and films including Elaan (1994), Hulchul (1995), Udaan (1997), Police Force (2004), Forensic (2022).