He was also exposed to the political vicissitudes of the time, as his father Asaf Al Safarjalani (in Arabic آصف السفرجلاني) had a leading role in the Great Syrian Revolution of 1925 against the French, who were then the mandatory power in Syria.

A distinguished attorney at young age, Al Safarjalani was on a path to a prominent public life and a rising figure in the Syrian political arena.

Quickly he was recognized and admired among his peers and was named for several government posts, among them, General Secretary of the Presidential Council and Governor of Latakia Province.

Nasim Al Safarjalani became the youngest ever Syrian Governor in the modern history of Syria.

On 23 February 1966 a bloody coup d'état led by leftist Ba'athist faction headed by Chief of Staff Salah Jadid, overthrew the Syrian Government.

Al Safarjalani was sentenced to death in absentia by a special military court headed by later Syrian Defence Minister, Mustafa Tlass, and Interim Syrian President and Vice President of Syria Abdul Halim Khaddam, as prosecutor.