In 1947, together with Michel Aflaq, he became a founding member of the Arab Socialist Ba'ath Party and from 1963 to 1964 he held different ministerial posts in the Syrian government.
In 1964 he was elected as General Secretary of the Syrian Regional Command of the Ba'ath Party and in 1965 he became Vice President of Syria under Amin al-Hafiz.
On 4 June 2011, during a visit to Lebanon, al-Aysami was kidnapped by unknown militants and is presumed dead.
[2] The Syrian government, however, blamed the Lebanese Druze leader Walid Jumblatt.
He was the great uncle of Tareck El Aissami, later Vice President of Venezuela.