[1] After school, he worked as an accountant and then went to work for the William Morris Agency in 1927 where he held a number of positions including comptroller, treasurer, executive vice president, president, and the chairmanship in 1976.
[1] His brother Julius Lefkowitz ran the outside accounting firm that William Morris agency used.
[2] In 1980, he was replaced by his protégé Morris Stoller after an acrimonious power struggle at the agency.
[3] Lefkowitz was active in served as the chairman of the Jewish Theatrical Guild, as an executive with the United Jewish Appeal, the Federation of Jewish Philanthropies, the Actors Fund, the Will Rogers Memorial Hospital, the O'Donnell Memorial Research Laboratories and the National Conference of Christians and Jews.
[1][7] His nephew was Ted Ashley, former chairman of the Warner Bros. film studio (1969–1980) and founder of the Ashley-Famous talent agency.