[1] Natalia attended Universidad del Norte, in Barranquilla, Colombia where she majored in social communications and journalism.

[2] In early 2000, Natalia moved to New York and worked for Spanish language Public TV on HITN (Hispanic Information and Telecommunications Network), where she also produced the shows "Corriente Cultural" and "NotiCultura".

[5][6] With only one month on the job, she covered the WTC terrorist attacks, being one of the first reporters on the scene at Ground Zero.

[21] Cruz often sits in as news anchor for shows at Univision, such as "Primer Impacto", "Despierta América", "Al Punto" and "Desayuno Alegre".

In 2012, Natalia hosted "Es el momento"[26] Special "Primeros pasos hacia el éxito", Highlighting the Importance of Early Childhood Education; recorded at The White House featured artist Shakira and U.S. Secretary of Education Arne Duncan among other experts.

[27] In March 2013 she conducted from the studios, Univision's first time ever live broadcast of Easter Mass from Vatican City celebrated by Pope Francis.