[2] Vikhlyantseva made her WTA Tour main-draw debut at the 2015 Shenzhen Open where she received a wildcard.

After winning two titles in 2016 on the ITF Circuit, she reached the semifinals of the Open de Limoges where she took top-seeded top-30 player Caroline Garcia to three sets.

Vikhlyantseva debuted at a Grand Slam tournament at the 2017 Australian Open where she reached the second round of the main draw, losing to Anastasia Pavlyuchenkova.

After some poor results which followed, Vikhlyantseva reached the second round at the Stanford Classic and at the Linz Open before coming up with a surprise run to the semifinals of the Kremlin Cup, where she had her first ever top-20 win over compatriot Elena Vesnina in straight sets.

Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.