From May 25–30, 2010, in Calgary, Spooner was invited to participate in the Canadian National Women's Program Strength and Conditioning Camp.

Spooner also played for Team Canada at the Ball Hockey World Championship in Pilsen, Czech Republic, from June 13–20, 2009.

Spooner participated in the inaugural IIHF World Women's U-18 Championships in January 2008 and won the silver medal.

In August 2007, the Canadian U-18 played a summer series against the U-18 Team USA squad, and Spooner was an assistant captain.

[3] In the gold medal game of the 2011 Four Nations Cup, Spooner scored two goals in a 4–3 loss to the USA.

[4] In a game versus Russia at the 2012 IIHF Women's World Championship, Spooner logged a hat trick in a 14–1 victory.

Spooner served as captain of the squad, leading it to the gold medal in the U-18 National Hockey Tournament after recovering from a broken jaw sustained in a PWHL game.

She broke her jaw in two places, had her mouth wired shut for five weeks and was limited to a liquid diet.

[9] Before committing to Ohio State for food science nutrition, approximately 30 universities and colleges expressed interest in her.

[10] On January 28–29, 2011, Spooner scored four goals and contributed six points as the Buckeyes swept conference rival St.

In Ohio State's 6–1 victory on January 28, Spooner recorded her third-career hat trick as well as an assist.

[13] On November 25, 2011, Spooner scored four goals for the third time in her NCAA career, including a natural hat trick as the Buckeyes enjoyed a home-ice conference victory over Minnesota Duluth.

The natural hat trick (three consecutive goals) was scored in the second period as the Buckeyes faced a 1–0 deficit against the Bulldogs.

Heading into the series, she was only three goals away from breaking the school record of 86 set by forward Jeni Creary.

After the game, Spooner had accumulated 140 career points (87 goals, 53 assists) to rank fourth in that category.

In a January 27, 2012 defeat of the North Dakota Fighting Sioux, Natalie Spooner finished the game with two goals as the Buckeyes prevailed by a 6–2 mark.

Spooner reached the 150 career point plateau with the goals, moving her into third all-time in Ohio State history.

Her 163 career points ranks second all-time among Buckeyes players, while her 16 game-winning goals are another program record.

Selected in the second round, 7th overall, by the Toronto Furies in the 2012 CWHL Draft, Spooner set a franchise record for most goals by a rookie.

Making her Toronto debut on October 20, 2012, in a road game at Brampton, Spooner scored a hat trick and assist, resulting in a four-point performance.

Spooner also provided the overtime heroics, logging the game-winning goal at the 1:26 mark of the extra frame, as Deluce gained her second assist of the night.

[24] Spooner became the first player in Furies history to reach the plateau of 90 career points, achieving the feat during the 2016–17 CWHL season.

[32] Along with Sochi teammate Meaghan Mikkelson, the pair were among the competing teams in the second season of The Amazing Race Canada in 2014.

[36] The renovation of Natalie and Adam's basement creating a home gym and laundry room was the focus of an episode of Save My Reno on HGTV in 2019.