During high school, Cloud led Cardinal O'Hara to the Pennsylvania Interscholastic Athletic Association Class AAAA state finals as a junior and to the second round as a senior.

Following her high school career, Cloud received a scholarship to play at the University of Maryland as a Terp.

[2] Her coach, Brenda Frese, stated that: Natasha is a very athletic and unselfish player who will do whatever her team needs to help us win.

[1] During the 2014 NCAA tournament, she scored 13 points, seven rebounds, four assists, two blocked shots, and two steals in a first round win over Georgia.

[5] In June 2020, Cloud announced that she would forgo the 2020 WNBA season due to concerns regarding the COVID-19 pandemic and a desire to focus on social justice advocacy.

[11] On August 27, 2024, it was announced that Cloud would appear and play in the inaugural season of Unrivaled, the women's 3x3 basketball league founded by Napheesa Collier and Breanna Stewart.

[14] Stats current through end of 2024 season Source[15] Cloud was married to professional softball player, Aleshia Ocasio in 2019.

[18] In February 2024, Cloud joined the WNBA Changemakers Collective and their collaboration with VOICEINSPORT (VIS) as a mentor, "aimed at keeping girls in sport and developing diverse leaders on the court and beyond the game.

"[19][20] In December 2020, Cloud was named to Forbes 30 Under 30 alongside fellow WNBA players A'ja Wilson and Chiney Ogwumike.