[1][2][3] Born in Lincolnwood, Illinois, Loyd was a four-year starter for Niles West High School in Skokie, Illinois, where she averaged 24.8 points and 11.9 rebounds per game and scored 3,077 career points, leading the team to a 93–31 record during that time.

While Bird sat out the final seven games of the regular season to rest, Loyd was the starting point guard.

In her second season, Loyd developed into a star player and was the starting shooting guard for the Storm, averaging 16.5 ppg.

The Storm were defeated 79–69 by the Phoenix Mercury in the first round elimination game, Loyd scored 17 points in the loss.

In the semi-finals, the Storm defeated the Phoenix Mercury in five games, advancing to the WNBA Finals for the first time since 2010.

In the Finals, the Storm defeated the Washington Mystics in a three-game sweep, winning their first championship in 8 years.

On June 21, 2019, Loyd scored a season-high 23 points while tying a career-high 5 three-pointers in an 82–64 victory over the Los Angeles Sparks.

On August 20, 2020, Loyd scored a new career-high 35 points in a 90–84 loss to the Indiana Fever, despite the pandemic the Storm had a fully loaded roster and finished 18–4 with the number two seed, receiving a double bye to the semi-finals.

In the semi-finals, the Storm would sweep the Minnesota Lynx in three games, advancing back to the Finals for the second time in three years.

[16] On July 13, 2024, it was announced that Loyd would appear and play in the inaugural 2025 season of Unrivaled, a new women's 3x3 basketball league founded by Napheesa Collier and Breanna Stewart.

[18] She and Team USA went on to win the gold medal in the tournament, defeating Japan 90–75 in the final.