Dowie played for the London teams Watford, Fulham and Charlton Athletic, and then spent five years with Everton before transferring to FA WSL clubs Liverpool Ladies in November 2012 and Doncaster Rovers Belles in 2016.

She also spent three periods on loan with Melbourne Victory of the Australian W-League in 2015, 2016, and 2017 and played for Boston Breakers in the National Women's Soccer League (NWSL) in 2016 and 2017.

[6] When Charlton Athletic scrapped their women's team in the 2007 close season,[7] Dowie joined Everton Ladies[2] in preference to several other interested clubs including Arsenal.

[11] She continued to play for Everton in European competition and netted in The Blues' UEFA Women's Champions League quarter–final defeat to FCR 2001 Duisburg.

[12] Dowie then scored two goals for Everton in their first FA WSL match, including a stoppage-time equaliser, to rescue a 3–3 draw at local rivals Liverpool.

[13] In November 2012 Dowie and Fara Williams left Everton for ambitious local rivals Liverpool, who were building a squad to challenge Arsenal's dominance of English women's football.

They finished seventh of eight teams amidst an injury crisis[16] and coach Matt Beard departed for American National Women's Soccer League (NWSL) club Boston Breakers.

[18] Doncaster lost their four opening games and were marooned at the foot of the WSL 1 table, when Dowie left the club by "mutual consent" in the mid-season break.

She came on as a substitute in England's first 2015 FIFA World Cup qualifier and scored her first national team goal in a 6–0 win over Belarus at Dean Court in Bournemouth.

[37][38] Dowie's continuing good form at club level meant it was something of a surprise when she was left out of England's 2015 FIFA Women's World Cup squad.

[48] Natasha's 2010 FA Women's Cup final goals against Arsenal Ladies came two hours after Hull City, managed by uncle Iain, were relegated from the Premier League.