[1] O'Keeffe first came to public attention in 2008, playing a member of the Royal Family who enjoys parties, one-night stands and drugs in the music video for "Falling Down",[1] the last single released by Oasis before the band dissolved.
In 2010 and 2012, O'Keeffe played Sadie in both seasons of BBC Three's drama series Lip Service, about a group of lesbians living in Glasgow, Scotland.
[1][2] In 2012 and 2013 she played Abbey Smith in the lead ensemble for the final two seasons of E4's comedy-drama Misfits, about a group of young offenders in a London community service program who obtain supernatural powers.
[3][4][5] In 2013, O'Keeffe had a role in an episode of Law & Order: UK, and appeared in the feature films Filth[2] and Svengali.
[6] She also starred in a music video for Daughter's song "Numbers" as part of a series of films for the band's album Not to Disappear.