He played in Major League Baseball (MLB) for the San Francisco Giants (2007–2012), Philadelphia Phillies (2012), Chicago Cubs (2013–2014), and Washington Nationals (2014).

[5][8] Entering the 2007 season, Schierholtz was ranked the eighth-best prospect in the Giants' organization by Baseball America.

He finished third in the league in batting average (.333, behind Geovany Soto's .353 and Delwyn Young's .337) and triples (seven, tied with Scott Seabol behind Reggie Abercrombie's and Jeff Salazar's nine).

[14] On June 23, at AT&T Park against the New York Yankees, he blooped an RBI single into center field against Scott Proctor in the bottom of the 13th inning to win the game 6–5 for the Giants.

In the sixth inning of a preliminary round game against China, he collided with China backup catcher Yang Yang at the home plate on a sacrifice fly, a play that resulted in a near brawl between the teams and saw Chinese manager Jim Lefebvre ejected from the game.

[19] Schierholtz played nine games with the Americans, batting .216 with four doubles, one home run, and six RBI as the United States earned a bronze medal.

[24][25][26] On June 14, he had an inside-the-park home run, only the fourth in AT&T Park history, in the third inning against Brett Anderson of the Oakland Athletics in a 7–1 victory.

[28] From July 28 through August 12, he was on the disabled list with a bruised left hip, which he suffered after running into a chain-link fence at Turner Field.

[5][29][30] He saw his playing time reduced in September as Winn moved back to right field to give Eugenio Vélez and John Bowker opportunities in left.

[5] Schierholtz was expected to be the Giants' Opening Day right fielder in 2010, but Bowker won the position after hitting six home runs in spring training.

[35] When Buster Posey was called up in late May, Aubrey Huff moved from first base to right field, leaving Schierholtz on the bench.

[35][37][39][40] When José Guillén was acquired on August 13, Schierholtz was relegated to the role of pinch-hitter and late-inning defensive substitution for the rest of the year.

[5] Schierholtz received regular playing time throughout the postseason as a defensive replacement for starting outfielder Pat Burrell.

This strategy was meant to provide the Giants with the best possible defensive outfield and, thus, the best chance of holding the lead and winning the game.

[47] Schierholtz hit a 467-foot home run at Coors Field on April 18, 2011, against Esmil Rogers in an 8–1 victory over the Rockies.

In the bottom of the 14th inning of that game, he hit a walk-off home run against Pat Neshek that secured a 6–5 victory for the Giants.

[55] Following the acquisition of Carlos Beltrán on July 28, Schierholtz began playing some left field for the first time in his career.

[58][59] On July 18, in an interview with Henry Schulman of the San Francisco Chronicle, he said that Bochy had told him in May that he did not view him as an everyday player.

"[60] That weekend, he started three games against the Philadelphia Phillies in right field, partly because Blanco and Ángel Pagán had been struggling.

[61] On July 22, Schierholtz hit two home runs against Joe Blanton, the second of which forced the game into extra innings.

[68][69] Despite being traded to the Phillies, Schierholtz received his second World Series ring from the Giants due to his contributions during the first half of the 2012 season with the team.

[76] Schierholtz reset his career-high in RBI with six on August 19, including home runs against Jordan Zimmermann and Fernando Abad in an 11–1 victory over the Washington Nationals.

[81] On September 21, he tripled home a run against Nate Eovaldi, then scored on a double by Anthony Rendon in a 2–1 victory over the Miami Marlins.

[85] After his release from Texas, Schierholtz went to Japan, signing a one-year deal with the Hiroshima Toyo Carp of Nippon Professional Baseball (NPB).

The fans are very kind to the American foreign players and it was a great experience," Schierholtz summarized his time in Japan.

[86] On December 23, 2015, Schierholtz signed a minor league contract with the Detroit Tigers, and was invited to 2016 spring training.

[87] Failing to make the club, he played 31 games for the Triple-A Toledo Mud Hens of the International League, batting .246 with 29 hits, three home runs, and 13 RBI before his release on May 22.

[6][1] On August 5, 2016, Schierholtz received an 80-game suspension from Major League Baseball for testing positive for a performance-enhancing drug.

[88] Schierholtz married Kate Eveland, a former guard on the San Diego State basketball team on December 3, 2011.