His other live-action film and television roles include Kenneth W. Dantley Jr. in Corvette Summer (1978), Private Griff in The Big Red One (1980), Crow in Sushi Girl (2012), Ted Mitchum in Brigsby Bear (2017), and Arthur Pym in the Netflix miniseries The Fall of the House of Usher (2023).

Aside from Joker, his other voice roles include the Hobgoblin in Spider-Man: The Animated Series (1995–1998), Fire Lord Ozai in Avatar: The Last Airbender (2005–2008), Mr. Salacia and Senator Stampingston in Metalocalypse (2006–2013, 2023), and Skips in Regular Show (2010–2017).

[6] Hamill has stated that he had a troubled relationship with his father who couldn't understand his childhood obsession with movies and comic books, seeing them as frivolous things that he should outgrow.

[8] At age 11, he moved to the 5900 block of Castleton Drive in San Diego, California, where he attended Hale Junior High School.

[10] By his junior year, his father was stationed in Japan, where Hamill attended and was a member of the Drama Club at Nile C. Kinnick High School, from which he graduated in 1969.

[17] During his screen test, Hamill presumed that he was playing a sidekick to Harrison Ford's Han Solo and was unsure whether or not the film was supposed to be a comedy.

[20] For his part in both of the sequels, Hamill was honored with the Saturn Award for Best Actor, given by the Academy of Science Fiction, Fantasy and Horror Films.

[23] Editions of Joseph Campbell's The Hero with a Thousand Faces (which influenced Lucas as he was developing the films) issued after the release of Star Wars in 1977 used the image of Hamill as Luke Skywalker on the cover.

[28] Following its acquisition of Lucasfilm, The Walt Disney Company released more Star Wars films, starting with The Force Awakens on December 18, 2015.

[35] Hamill was initially critical of his own role in the film, stating that he and director Rian Johnson had "a fundamental difference" regarding Skywalker's characterization.

[41] Hamill was digitally de-aged to reprise his role as Skywalker in the season 2 finale of The Mandalorian[42] and the sixth chapter of the spin-off series The Book of Boba Fett.

[47] Further distancing himself from his early blockbuster role, Hamill started acting on Broadway, starring in plays such as The Elephant Man (1979),[48] Amadeus (1983),[49] Harrigan 'N Hart (1985, for which he received a Drama Desk Award nomination),[50] Room Service (1986)[51] and The Nerd (1987–88).

[73] Hamill appears in Squadron 42—the single-player campaign from the Star Citizen computer-game universe—as Lieutenant Commander Steve "Old Man" Colton.

He and his crew shot most of the "mockumentary" film during the 2002 San Diego Comic-Con and enlisted Stan Lee, Kevin Smith, Bruce Campbell and Hugh Hefner in small roles.

[82] He also made a guest appearance alongside George Takei in the season one finale of the ABC sitcom The Neighbors as Commandant Bill.

[86] In 2014, Hamill appeared in the film Kingsman: The Secret Service as James Arnold, a professor from Imperial College London and an expert on climate change.

[89] In April 2022, it was announced that Hamill would make an appearance on the revival of the series The Kids in the Hall, which was set to be released on Amazon Prime Video the following month, on May 13.

The voice role he is most known for is Batman's archenemy the Joker,[27] the success of which has led him to portray a wide variety of characters in television, film, anime, and video games (mostly similar super-villains).

[citation needed] Non-comic-related television roles include the deranged shock jock anchorman Dr. Jak in Phantom 2040; Principal John Smith in the Totally Spies episode "Soul Collector"; Christopher "Maverick" Blair in Wing Commander Academy; the Walter Lantz character Buzz Buzzard in The New Woody Woodpecker Show; the flamboyant robot Lawrance "Larry" 3000 in Time Squad; the pirate Captain Stickybeard in Codename: Kids Next Door; Fire Lord Ozai in Avatar: The Last Airbender, the Skeleton King in Super Robot Monkey Team Hyperforce Go!

[93] Hamill's video game voice roles include Detective Mosely in Gabriel Knight: Sins of the Fathers and Gabriel Knight 3: Blood of the Sacred, Blood of the Damned; Assistant Director Wilson in Soldier of Fortune II: Double Helix; Adrian Ripburger in the LucasArts game Full Throttle; Wolverine in X2: Wolverine's Revenge (the game which accompanied the film X2); Goro Majima in Yakuza; Malefor The Dark Master in The Legend of Spyro: Dawn of the Dragon; The Watcher in Darksiders; and Master Eraqus in Kingdom Hearts Birth by Sleep and Kingdom Hearts III.

[98] In 2021, Hamill voiced the tailor Art Rosenbaum in the animated adaptation of Robert Kirkman's Invincible series, and Skeletor in Masters of the Universe: Revelation.

[104] At San Diego Comic-Con 2024, it was announced that Hamill would replace Brian Doyle-Murray as the voice of The Flying Dutchman in The SpongeBob Movie: Search for SquarePants.

[107] The short-lived The WB live-action series Birds of Prey, based on the comic book of the same title, featured a flashback sequence in which the Joker shoots Barbara Gordon and paralyzes her.

[120] Hamill has commented that if there would ever be an animated version of Batman: The Killing Joke, he would gladly voice the Joker again, encouraging fans to campaign for said adaptation.

[130] In July 2024, he made a brief appearance in the film Justice League: Crisis on Infinite Earths – Part Three as the Joker alongside Conroy as Batman (in the latter's final posthumous performance as the character).

After encountering writer Chris Elliott, Hamill was asked for assistance in helping determine the 1,000th Viewer Mail that Letterman had answered.

[141] Nathan was born during the production of The Empire Strikes Back and had a cameo appearance as one of the Royal Guards of Naboo in Star Wars: Episode I – The Phantom Menace.

[146] Prior to the 2008 presidential election, Hamill urged students at Point Park University to vote for Barack Obama, describing him as "a once in a lifetime candidate".

[151] During the 2022 Brazilian general election, Hamill expressed support for Workers' Party candidate Luiz Inácio Lula da Silva.

[152] In October 2023, Hamill, along with over 700 other Hollywood professionals, signed an open letter condemning the Palestinian militant group Hamas, demanding the release of hostages held in Gaza, and expressing support for Israel in the Israel–Hamas war.