Zinchenko began his career at Russian Premier League team Ufa before joining Manchester City in 2016 for a fee around £1.7 million.

[note 1] He made his Russian Premier League debut for Ufa on 20 March 2015 in a match against FC Krasnodar.

[13] On 4 July 2016, Zinchenko signed for Premier League club Manchester City for an undisclosed fee believed to be around £1.7 million.

[18] Zinchenko returned to Manchester City for the 2017–18 season, and made his debut on 24 October 2017, playing the full match including extra time in a 0–0 draw with Wolverhampton Wanderers in the EFL Cup.

[21] Zinchenko gained an extended run in the side following injuries to left backs Benjamin Mendy and Fabian Delph, putting in a number of consistent performances in the position.

In the same week, he made his first league start of the season in a 2–0 home win against Brighton & Hove Albion, due to injuries to Mendy and Delph.

[23] Zinchenko scored his first goal for Manchester City in the EFL Cup semi-final against Burton Albion on 9 January 2019, a 9–0 home win.

[30] On 4 May 2021, Zinchenko was a part of the starting XI that saw Manchester City qualify for their first UEFA Champions League final, after beating Paris Saint-Germain 2–0 on the night and 4–1 on aggregate.

[32] On the final matchday of the 2021–22 season, he came on as a substitute and earned an assist against Aston Villa, overturning a two-goal deficit to eventually win the game 3–2 to hand him his fourth Premier League medal.

[40] Zincenko also became Ukraine's youngest player to score an international goal at the age of 19 years and 165 days, beating a record held since 1996 by Andriy Shevchenko.

[41] On 24 March 2021, in a match against France, Zinchenko became Ukraine's youngest player captain in their history at the age 24 years and 98 days.

On 24 February 2022, he wrote on his Instagram that he wished for Vladimir Putin, the President of Russia, to die the most painful of deaths.

[51] In an interview with the BBC in April 2024, Zinchenko expressed his willingness to fight in his home country should he be called up, and said that he had donated about £1 million to help people affected by the war in Ukraine.