Major General Nathan Mugisha is a military officer in Uganda People's Defence Force.

[2] Prior to that, he served as the Commander of the African Union Mission to Somalia (AMISOM), June 2009 until June 2011, being the third military officer to serve in that capacity.

Under General Nathan Mugisha's command, AMISOM repelled the "Ramadan Offensive" launched by al-Shabaab during August 2010.

He attended Ugandan schools prior to joining the Military of Uganda.

In June 2005, at the rank of colonel, he was the commanding officer of the 4th Division of the Uganda People's Defence Force, based in the Northern Ugandan city of Gulu.