Nathaniel W. Depee (1812 – June 19, 1868) was an American activist, abolitionist, and merchant tailor.

[2][3] Nathaniel W. Depee was born in 1812 in Philadelphia, Pennsylvania, U.S.[4] In 1845, Depee helped to form the Colored American National Society, an organization that helped connect the Colored Conventions Movement and William Whipper's American Moral Reform Society.

[1] In 1855, Depee served as a delegate at the 1855 National Colored Convention in Philadelphia.

[1] Depee was one of five members of the acting committee for the Vigilant Association of Philadelphia, others included William Still, Jacob C. White, Passmore Williamson, and Charles Wise.

[5][6] His home at 334 South Street was listed as one of the Underground Railroad stops.