The station, located below grade in a wide cut adjacent to North Main Street (Route 27), has two side platforms serving the line's two tracks.

[2] Stations on the branch included Felchville (at Fisher Street), Cochituate (at Commonwealth Road on the Natick/Framingham border), and Saxonville.

[3] The lightly used Saxonville Branch never saw more than three daily round trips; passenger service was discontinued effective February 17, 1936.

[11] The inbound side of the station is supported by the rear wall of the liquor store, decorated with a colorful mural of the Downtown Natick area.

A second station serving the town opened at West Natick in 1982 to provide additional parking.

Inbound ridership in 2018 was 736 passengers, making Natick Center the second-busiest non-accessible station on the MBTA Commuter Rail system.

[22] In July 2014, the MBTA agreed to the town's request to change the station's name as part of a larger rebranding of the Natick Center area.

[20] Online maps were changed shortly thereafter, and on January 12, 2015, the station was officially renamed as Natick Center.

[23] In March 2016, $4 million for completing design of the station was included in a draft 2017–2021 MBTA capital plan.

[30] In July 2020, the state awarded $125,000 for design of the final 1,300-foot (400 m) segment of the Cochituate Rail Trail, including the connection with the new station.

[32] In February 2022, the MBTA indicated that completion would be delayed to early 2024 due to supply chain issues and soil conditions requiring modification of a retaining wall design.