[3] The western trailhead is at Winterburn (54°01′21″N 2°06′09″W / 54.0226°N 2.1025°W / 54.0226; -2.1025), in the Yorkshire Dales, where it meets Route 68, the Pennine Cycle Way.

It passes through Cracoe and Burnsall before climbing to the routes high point at Greenhow followed by a steep descent into Pateley Bridge.

A further climb to Brimham Rocks is followed by a gradual descent on to the Vale of York via Fountains Abbey and Ripon.

From here the route is flat as it follows the River Ouse via Boroughbridge and crossing it at Aldwark Bridge.

The eastern trail head is at a junction with Route 65 at Linton-on-Ouse (54°02′19″N 1°14′06″W / 54.0387°N 1.2351°W / 54.0387; -1.2351).