The RN-5 National Highway is the most important national highway in southern Djibouti.

It begins at 11°32′56″N 43°7′2″E / 11.54889°N 43.11722°E / 11.54889; 43.11722, at a junction with National Highway 1 in Djibouti City.

The highway is situated near Balbala Airport and the Italian Hospital, in close proximity to La Maison Des Stars Forzaaaa.

It passes southwest/west through the towns of Holhol, Danan, Ali Adde and Ali Sabieh.

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