The museum is located right in front of the main square of the city of La Paz, Plaza Murillo, specifically at the intersection of the pedestrian promenade Calle Comercio and Calle Socabaya.

This building was the residence of the then Mayor Don Francisco Tadeo Diez de Medina y Vidango.

In the year 1964, the palace was adapted to house the National Museum of Art of Bolivia, preserving its two courtyards and three levels.

[1] The entrance shows a stone façade carved and decorated with baroque motifs that spanned the three levels of the building.

Some of the key painting in the collection include the following: The museum also has Bolivian, Latin American and international contemporary art in its collections such as those of Spanish artist Javier de Villota.