He later became a full-time professor of pathology at the Faculty of Medicine in the University of Khartoum in 1952 was succeeded by Mansour Ali Haseeb who became the first Sudanese director of the laboratory.

[7] Haseeb, who is considered the "Godfather Of Sudan's Laboratory Medicine",[11][12][13] conducted research on various endemic diseases and collaborated on successful experiments regarding smallpox vaccine production.

Within the laboratories, he formulated plans for training Bachelor of Science graduates in the United Kingdom in biomedical subjects such as schistosomiasis and entomology.

Situated adjacent to the old Stack Medical Research Laboratories buildings, the new five-story structure spans approximately 9,000 square metres (97,000 sq ft).

[22][23][24] The next day Member of the Transitional Sovereignty Council and Chairman of the Supreme Committee for Health Emergencies, Abdel-Baqi Abdel-Qader Al-Zubair, accompanied by the Acting Governor of Khartoum, Ahmed Othman Hamza, made a visit to the NPHL and asked for the facilities to be protected and secured.

[22][25] On 25 April 2023, during the Sudanese civil war, armed forces took control of the NPHL, and expelled its staff responsible for managing biological hazards.

The laboratory's vital functions are crucial, especially during the rainy season, when the increased risk of floods and disease outbreaks demands enhanced public health emergency preparedness and response capabilities.

[30] Since 8 September 2023, the NPHL moved from Khartoum to Port Sudan, east of the country, as a result of it being subjected to sabotage and destruction due to the war that has been going on there since last April 15.

Each department within the NPHL contributes, to varying degrees, to research addressing medical issues associated with endemic diseases in Sudan.

[7] Activities at the NPHL encompassed teaching medical students and auxiliary staff, conducting routine diagnostic work and vaccine preparation, and researching endemic and epidemic diseases,[7] such as coronavirus.

[34][35] Research primarily aimed to address specific problems related to endemic diseases or assist in epidemic control measures.

Routine activities included diagnostic examinations of patient specimens from hospitals and vaccine preparation for diseases such as smallpox, rabies, cholera, and tuberculosis.