From its start in km marker 496 of National Route 14 until its end at the Paso de los Libres-Uruguaiana International Bridge (crossing the Uruguay River) unites the cities of Paso de los Libres, Argentina and Uruguaiana, Brazil for a total length of 12.9 kilometres (8 mi).

Milestones: In 1990 a federal law decreed the development of the most travelled national routes by means of concessions to private companies in delineated Corredores Viales (Road Corridors).

Designated Corredor Vial 18, it was given to the company that had the winning bid, Caminos del Río Uruguay S.A. (CRUSA).

[1] In 1996 the concession was extended to 28 years under the condition that the winning bidder built a highway between the Zárate-Brazo Largo Bridge and Gualeguaychú.

The section between the General Justo José de Urquiza Bridge and Ceibas (corresponding to National Route 12) was completed on 12 October 1999.