Starting south of the city of Zárate in Buenos Aires Province, and crossing the Paraná River, through the Zárate-Brazo Largo Bridge, continues to the provincial capitals of Paraná, Corrientes and Posadas, ending at the Fraternity Bridge, in the city of Puerto Iguazú, bordering with Brazil.

[3] National Law 25,680 published in the Official Bulletin on 3 January 2003 designates the section from Brazo Largo to Ceibas as David Della Chiesa road.

In 1990 concessions were leased with toll collection on the busiest national roads, dividing the country in zones called "Corredores Viales".

[5] In 1996 the concession was extended to 28 years with the condicion that the bidding company built a highway between the Complejo Unión Nacional and Gualeguaychú.

The section between the General Justo José de Urquiza bridge and Ceibas was completed on October 12, 1999.

[5][6] In 2003 the Corredores Viales concession contracts expired, and the numbering system was changed when calling for a new bidding process.

The original road started in Buenos Aires, passing through General Pacheco, Campana and Zárate.