Villaguay is a city in the province of Entre Ríos in the Argentine Mesopotamia.

The city lies near the geographic center of the province, east of the Gualeguay River, on National Route 18 (which links it to Paraná, the provincial capital, located 155 km to the west, and to Concordia, 120 km east).

In the nineteenth century, Spanish, Jewish, French, Italian, Volga German, and Belgian communities were established in the area.

In 1873, Villaguay, previously administered by military commanders, became a municipality.

This article about a place in Entre Ríos Province, Argentina is a stub.